Coley’s Cancer-Killing Concoction

From DamnInteresting.com.

Dr. William Coley (1862–1936) was an American bone surgeon and cancer researcher, pioneer of cancer immunotherapy. He developed a treatment based on provoking an immune response to bacteria.

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Coley’s discovery, as it turns out, was actually a re-discovery. The idea of a link between acute infection and the resolution of tumours was not new, and the phenomenon of infection-related “spontaneous regression” of cancer has been documented throughout history. A 13th century Italian saint was reputed to have his tumour-afflicted leg miraculously healed shortly after the malignant growth burst through the skin and became infected. Crude cancer immunotherapies working along similar lines to Coley’s early experiments were known in the 18th and 19th centuries, and may extend back to the time of the pharaohs. Ancient writings suggest that the renowned Egyptian physician Imhotep may have used a similar infect-and-incise method to treat tumours.

But Coley took those first important steps in dragging this old remedy into the twentieth century. After the fatalities with the ‘live’ version of his therapy, he developed an improved fluid containing killed bacteria of two different strains, Streptococcus pyogenes and Serratia marcescens. This was based on the idea that the dead bacteria would still have the immune-stimulating capability of their living brethren (in the form of purported ‘toxins’), but not share their inconvenient tendency to cause death. His invention became variously known as ‘Coley’s Toxins’, ‘Coley’s Vaccine’, ‘Mixed Bacterial Toxins’ or ‘Coley Fluid.’
..

Due partly to the fact that the treatment mechanism isn’t fully understood and the development of radiation therapy and chemotherapy, Coley’s Toxins is rarely used in the treatment of cancer thereafter.
The idea here is the body’s own defence and repair network can/may make a real difference in the battle against cancer.


2 Comments

  1. sky
    Posted November 19, 2007 at 11:10 pm | Permalink

    Immune system can drive cancers into dormant state. (Physorg)

    A multinational team of researchers has shown for the first time that the immune system can stop the growth of a cancerous tumor without actually killing it. The results also may help explain why some tumors seem to suddenly stop growing and go into a lasting period of dormancy.

    Equilibrium sometimes may be a more common outcome of tumor-immune encounters than elimination. According to the researchers’ theory, some of us may harbor dormant tumors that either developed spontaneously or from exposure to carcinogens. They propose that these quiescent tumors are unleashed only as we age or are exposed to environmental, infectious or physical stresses that cause a breakdown of the immune system.

    To follow up, researchers plan a molecular-level investigation of what happens in tumors and the immune system during equilibrium. They also want to test their results’ applicability both in humans and in different types of cancers.

  2. sky
    Posted August 19, 2008 at 10:49 pm | Permalink

    Antibodies from 1918 flu pandemic found in survivors living today. (IHT)
    Nine decades after history’s most lethal flu faded away, survivors’ bloodstreams still carry highly potent protection against the 1918 virus, demonstrating the remarkable durability of the human immune system.
    Researchers manipulated those antibodies into a vaccine and found that it kept alive all the mice they had injected with the killer flu, according to a study published online Sunday in the journal Nature.

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